Failure of FIV-infected cats to control Toxoplasma gondii correlates with reduced IL2, IL6, and IL12 and elevated IL10 expression by lymph node T cells.

@article{Levy2004FailureOF,
  title={Failure of FIV-infected cats to control Toxoplasma gondii correlates with reduced IL2, IL6, and IL12 and elevated IL10 expression by lymph node T cells.},
  author={J K Levy and Yinghua Liang and Jerry W. Ritchey and Michael G. Davidson and Wayne A. F. Tompkins and Mary B. Tompkins},
  journal={Veterinary immunology and immunopathology},
  year={2004},
  volume={98 1-2},
  pages={101-11}
}
Increased susceptibility to intracellular pathogens in HIV-infected individuals and FIV-infected cats is attributed to a defective T-helper 1 (Th1) immune response. However, little is known about specific cytokine responses to secondary pathogens. To address this question, control and FIV-infected cats were challenged with Toxoplasma gondii, and lymph node cells analyzed for cytokine mRNA expression. Twenty-four weeks post-FIV infection, prior to T. gondii challenge, IL2 and IL12 mRNAs were… CONTINUE READING