Failure of Bay K 8644 to induce RhoA kinase-dependent calcium sensitization in rabbit blood vessels.

@article{Alvarez2010FailureOB,
  title={Failure of Bay K 8644 to induce RhoA kinase-dependent calcium sensitization in rabbit blood vessels.},
  author={Silvina M. Alvarez and Amy S. Miner and Brendan Michael Browne and Paul H Ratz},
  journal={British journal of pharmacology},
  year={2010},
  volume={160 6},
  pages={1326-37}
}
BACKGROUND AND PURPOSE RhoA kinase (ROCK) participates in K(+) depolarization (KCl)-induced Ca(2+) sensitization of contraction. Whether constitutive, depolarization- or Ca(2+)-activated ROCK plays the major role in this signalling system remains to be determined. Here, we determined whether Bay K 8644, a dihydropyridine that promotes Ca(2+) channel clusters to operate in a persistent Ca(2+) influx mode, could cause ROCK-dependent Ca(2+) sensitization. EXPERIMENTAL APPROACH Renal and femoral… CONTINUE READING

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