Failure of Bay K 8644 to induce RhoA kinase-dependent calcium sensitization in rabbit blood vessels.

  title={Failure of Bay K 8644 to induce RhoA kinase-dependent calcium sensitization in rabbit blood vessels.},
  author={Silvina M. Alvarez and Amy S. Miner and Brendan Michael Browne and Paul H Ratz},
  journal={British journal of pharmacology},
  volume={160 6},
BACKGROUND AND PURPOSE RhoA kinase (ROCK) participates in K(+) depolarization (KCl)-induced Ca(2+) sensitization of contraction. Whether constitutive, depolarization- or Ca(2+)-activated ROCK plays the major role in this signalling system remains to be determined. Here, we determined whether Bay K 8644, a dihydropyridine that promotes Ca(2+) channel clusters to operate in a persistent Ca(2+) influx mode, could cause ROCK-dependent Ca(2+) sensitization. EXPERIMENTAL APPROACH Renal and femoral… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 13 extracted citations

Alpha2C-adrenoceptors play a prominent role in sympathetic constriction of porcine pulmonary arteries

Naunyn-Schmiedeberg's Archives of Pharmacology • 2012
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 51 references

The selectivity of protein kinase inhibitors: a further update.

The Biochemical journal • 2007
View 4 Excerpts
Highly Influenced

Rho signaling: agonist stimulation and depolarization come together.

Circulation research • 2003
View 9 Excerpts
Highly Influenced

KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase.

American journal of physiology. Lung cellular and molecular physiology • 2004
View 6 Excerpts
Highly Influenced

The function of myosin and myosin light chain kinase phosphorylation in smooth muscle.

Annual review of pharmacology and toxicology • 1985
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…