Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue.

@article{Baarle2002FailingIC,
  title={Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue.},
  author={Debbie van Baarle and Stefan Kostense and Marinus H J van Oers and Dorte Hamann and Frank A Miedema},
  journal={Trends in immunology},
  year={2002},
  volume={23 12},
  pages={586-91}
}
Despite readily detectable virus-specific CD8(+) T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated… CONTINUE READING

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