Failed fertilization after clinical intracytoplasmic sperm injection.

  title={Failed fertilization after clinical intracytoplasmic sperm injection.},
  author={Murid Javed and Navid Esfandiari and Robert F. Casper},
  journal={Reproductive biomedicine online},
  volume={20 1},
Intracytoplasmic sperm injection (ICSI) has resulted in pregnancy and birth for many couples, including those with severe male factor infertility. However, even after ICSI, complete failure of fertilization occurs in 1-3% of cycles. Most cases occur due to low number of mature oocytes, failure of oocyte activation or non-availability of appropriate spermatozoa for injection. Given the significant emotional and financial involvement in assisted reproductive cycles, failure of fertilization in… CONTINUE READING
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