Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer

@article{Hardt2004FaecalTM,
  title={Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer},
  author={Philip D Hardt and Sybille Mazurek and Max Toepler and P. Schlierbach and Reinhard Georg Bretzel and Erich Eigenbrodt and H U Kloer},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={980 - 984}
}
Proliferating cells, especially tumour cells, express a special isoenzyme of pyruvate kinase, termed M2-PK, which can occur in a tetrameric form with a high affinity to its substrate, phosphoenolpyruvate (PEP), and in a dimeric form with a low PEP affinity. In tumour cells, the dimeric form is usually predominant and is therefore termed Tumour M2-PK. The levels of Tumour M2-PK within tumours and in EDTA-plasma correlate with staging and the ability of the tumour cells to metastasise. Since most… CONTINUE READING
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