Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer

  title={Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer},
  author={P. Hardt and S. Mazurek and M. Toepler and P. Schlierbach and R. Bretzel and E. Eigenbrodt and H. Kloer},
  journal={British Journal of Cancer},
  pages={980 - 984}
  • P. Hardt, S. Mazurek, +4 authors H. Kloer
  • Published 2004
  • Biology, Medicine
  • British Journal of Cancer
  • Proliferating cells, especially tumour cells, express a special isoenzyme of pyruvate kinase, termed M2-PK, which can occur in a tetrameric form with a high affinity to its substrate, phosphoenolpyruvate (PEP), and in a dimeric form with a low PEP affinity. In tumour cells, the dimeric form is usually predominant and is therefore termed Tumour M2-PK. The levels of Tumour M2-PK within tumours and in EDTA-plasma correlate with staging and the ability of the tumour cells to metastasise. Since most… CONTINUE READING
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