Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer

@article{Hardt2004FaecalTM,
  title={Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer},
  author={P. Hardt and S. Mazurek and M. Toepler and P. Schlierbach and R. Bretzel and E. Eigenbrodt and H. Kloer},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={980 - 984}
}
  • P. Hardt, S. Mazurek, +4 authors H. Kloer
  • Published 2004
  • Biology, Medicine
  • British Journal of Cancer
  • Proliferating cells, especially tumour cells, express a special isoenzyme of pyruvate kinase, termed M2-PK, which can occur in a tetrameric form with a high affinity to its substrate, phosphoenolpyruvate (PEP), and in a dimeric form with a low PEP affinity. In tumour cells, the dimeric form is usually predominant and is therefore termed Tumour M2-PK. The levels of Tumour M2-PK within tumours and in EDTA-plasma correlate with staging and the ability of the tumour cells to metastasise. Since most… CONTINUE READING
    120 Citations

    Figures, Tables, and Topics from this paper.

    Tumour M2-pyruvate kinase: a gastrointestinal cancer marker
    • 76
    • PDF
    Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
    • 7
    Tumor M2 pyruvate kinase: a tumor marker and its clinical application in gastrointestinal malignancy
    • 24
    • PDF
    Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study
    • 48
    • Highly Influenced
    • PDF
    Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours.
    • S. Mazurek
    • Chemistry, Medicine
    • Ernst Schering Foundation symposium proceedings
    • 2007
    • 71
    Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.
    • 19
    • PDF

    References

    SHOWING 1-10 OF 67 REFERENCES
    Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas.
    • 69
    The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma.
    • 60
    Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastro-intestinal cancer.
    • 69
    Tumor type M2 pyruvate kinase expression in advanced breast cancer.
    • 84
    Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
    • 67
    Double role of pyruvate kinase type M2 in the regulation of phosphometabolite pools
    • 22
    Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells.
    • 61