Faecal microbiota transplantation for Clostridium difficile‐associated diarrhoea: a systematic review of randomised controlled trials

@article{Moayyedi2017FaecalMT,
  title={Faecal microbiota transplantation for Clostridium difficile‐associated diarrhoea: a systematic review of randomised controlled trials},
  author={P. Moayyedi and Yuhong Yuan and Harith Baharith and A. Ford},
  journal={Medical Journal of Australia},
  year={2017},
  volume={207}
}
Objectives: Faecal microbiota transplantation (FMT) has emerged as a useful approach for treating Clostridium difficile‐associated diarrhoea (CDAD). Randomised controlled trials (RCTs) have recently evaluated its effectiveness, but systematic reviews have focused on evidence from case series. We therefore conducted a systematic review and meta‐analysis of RCTs evaluating the effectiveness of FMT for treating CDAD. 
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Current and emerging therapies in CDI management including antibiotics, fecal microbiota transplantation, monoclonal antibodies, spore-based therapies, and vaccinations are summarized. Expand
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In the initial feasibility study, FMT using a frozen inoculum from unrelated donors is effective in treating relapsing CDI and NGT administration appears to be as effective as colonoscopy administration. Expand
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