Fadd and Skp2 are possible downstream targets of RUNX1-EVI1.

Abstract

RUNX1-EVI1 generated by t(3;21) is a causative gene in the leukemic transformation of chronic hematopoietic stem cell tumors. Recruitment of histone deacetylase via carboxyl terminal-binding protein by RUNX1-EVI1 results in transcriptional dysregulation in target genes of wild-type RUNX1, leading to differentiation block and apoptotic prevention of myeloid… (More)
DOI: 10.1007/s12185-012-1232-5

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