Facts on fats
@article{Chong2006FactsOF,
title={Facts on fats},
author={Elaine W T Chong and Andrew J Sinclair and Robyn H. Guymer},
journal={Clinical \& Experimental Ophthalmology},
year={2006},
volume={34}
}Cardiovascular disease and age‐related macular degeneration (AMD) may share common risk factors in their causal pathways. Decades of research from the cardiovascular sciences on fats have led investigators to focus on specific types of fats rather than total fat as a whole. They have established that saturated and trans‐unsaturated fats (trans fats) are damaging to cardiovascular health while polyunsaturated fats, particularly the marine omega 3 fatty acids appear protective. This has led to a…
42 Citations
Fat consumption and its association with age-related macular degeneration.
- MedicineArchives of ophthalmology
- 2009
A diet low in trans-unsaturated fat and rich in omega-3 fatty acids and olive oil may reduce the risk of age-related macular degeneration.
Lifestyle and age-related macular degeneration
- Medicine
- 2009
Modification of ‘at risk’ lifestyles generally, and especially in those with a family history of AMD and those with early signs of the disease, may reduce the development/progression of this blinding disease.
Retina and Omega-3
- MedicineJournal of nutrition and metabolism
- 2011
This paper underscores the potential beneficial effect of omega-3 fatty acids on retinal diseases by suggesting western populations, particularly aged individuals, have a higher than optimal omega-6/omega-3 ratio and should enrich their diet with more fish consumption or have DHA supplementation.
Omega-3 fatty acids and cardiovascular disease.
- MedicineEuropean review for medical and pharmacological sciences
- 2015
Omega-3 fatty acids have been shown to significantly reduce the risk for sudden death caused by cardiac arrhythmias and all-cause mortality in patients with known coronary heart disease and hyperlipidemia and hypertension.
Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis.
- MedicineArchives of ophthalmology
- 2008
It is suggested that consumption of fish and foods rich in omega-3 fatty acids may be associated with a lower risk of AMD, and there is insufficient evidence from the current literature, with few prospective studies and no randomized clinical trials, to support their routine consumption for AMD prevention.
Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells.
- BiologyMolecular nutrition & food research
- 2009
Specific unsaturated fatty acids, particularly LA, can stimulate RPE cells to express proinflammatory genes, which may contribute to the pathogenesis of AMD.
Dietary -3 Fatty Acid and Fish Intake in the Primary Prevention of Age-Related Macular Degeneration
- Medicine
- 2008
Methods: Seven databases were systematically searched with no limits on publication year or language using standardized criteria. Randomized controlled trials and prospective cohort, case-control,…
A High-Fat/High-Cholesterol Diet Inhibits Growth of Fetal Hippocampal Transplants via Increased Inflammation
- Biology, MedicineCell transplantation
- 2011
Significant effects of the HFHC diet on hippocampal morphology, including elevated microglial activation and reduced neuronal development are demonstrated, suggesting a potential use for this agent in neurological disorders involving neuroinflammation.
The Trans Fatty Acid Content of Snacks Offered in Kermanshah
- Materials Science
- 2015
It is confirmed that Iranian snack foods contain high TFA levels due to use of hydrogenated fat by food processing companies, and according to the adverse health effect of TFAs they need to be minimized or eliminated from foods, it is strongly recommend that hydrogenatedFat should replace with other safe, edible oils, with minimal content ofTFAs.
References
SHOWING 1-10 OF 70 REFERENCES
Prospective study of dietary fat and the risk of age-related macular degeneration.
- MedicineThe American journal of clinical nutrition
- 2001
Total fat intake was positively associated with risk of AMD, which may have been due to intakes of individual fatty acids, such as linolenic acid, rather than to total fat intakes per se.
Types of Dietary Fat and Risk of Coronary Heart Disease: A Critical Review
- MedicineJournal of the American College of Nutrition
- 2001
Evidence from epidemiologic studies and dietary intervention trials addressing the relationship between dietary fat intake and risk of CHD is reviewed, with a particular emphasis on different major types of fat, n-3 fatty acids and the optimal balance between n- 3 and n-6 fatty acids.
Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake.
- MedicineArchives of ophthalmology
- 2003
Among individuals with the early or intermediate stages of AMD, total and specific types of fat intake, as well as some fat-containing food groups, modified the risk of progression to advanced AMD.
Omega 3 fatty acids and cardiovascular disease—fishing for a natural treatment
- MedicineBMJ : British Medical Journal
- 2004
The current evidence regarding fish oils and cardiovascular disease, their possible mechanism of action, and potential future developments and research strategies are reviewed.
The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease.
- MedicineThe Journal of nutrition
- 2002
Five controlled, peer-reviewed, human clinical walnut intervention trials, involving approximately 200 subjects representative of the 51% of the adult population in the United States at risk of coronary heart disease were reviewed and consistently demonstrated walnuts as part of a heart-healthy diet, lower blood cholesterol concentrations.
Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk.
- Biology, MedicineThe American journal of clinical nutrition
- 1999
Results suggest that there are non-fatty acid constituents in nuts that have additional cholesterol-lowering effects and further studies are needed to identify these constituents and establish their relative cholesterol- Lowering potency.
Trans fatty acids in adipose tissue and the food supply are associated with myocardial infarction.
- MedicineThe Journal of nutrition
- 2004
It is concluded that TFAs in adipose tissue are associated with an increased risk of coronary artery disease and rapidly disappear from adipOSE tissue when not included in margarines.
Dietary fat and risk for advanced age-related macular degeneration.
- MedicineArchives of ophthalmology
- 2001
Higher intake of specific types of fat--including vegetable, monounsaturated, and polyunsaturated fats and linoleic acid--rather than total fat intake may be associated with a greater risk for advanced AMD.
Trans fatty acids: are the effects only marginal?
- Medicine, ChemistryAmerican journal of public health
- 1994
The combined results of metabolic and epidemiological studies provide strong evidence that trans fatty acid intake is causally related to risk of coronary disease and federal regulations should require manufacturers to include trans fatty acids content in food labels and should aim to greatly reduce or eliminate the use of partially hydrogenated vegetable fats.
Relationship of dietary fat to age-related maculopathy in the Third National Health and Nutrition Examination Survey.
- MedicineArchives of ophthalmology
- 2001
Age-related maculopathy was not significantly associated with dietary fat in this large cross-sectional survey and further adjustments for other potential confounders did not significantly affect the ORs.