Factors that influence the penetration of methotrexate through solid tissue

@article{Cowan2001FactorsTI,
  title={Factors that influence the penetration of methotrexate through solid tissue},
  author={David S. Cowan and Ian F. Tannock},
  journal={International Journal of Cancer},
  year={2001},
  volume={91}
}
Limited penetration of anticancer drugs through tumour tissue is an important factor that may limit therapeutic effects against solid tumours. Here we report studies of the penetration of radiolabelled methotrexate through multicellular layers (MCL) of murine EMT‐6 and human MCF‐7 cells grown on semiporous teflon membranes. The penetration of methotrexate was only about 25% of that through the teflon membrane alone after 6 hr. This was true for all methotrexate concentrations examined from 10… Expand
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