Factors that Influence the Immunological Adjuvant Effect of Lactobacillus fermentum PC1 on Specific Immune Responses in Mice to Orally Administered Antigens

@inproceedings{Esvaran2016FactorsTI,
  title={Factors that Influence the Immunological Adjuvant Effect of Lactobacillus fermentum PC1 on Specific Immune Responses in Mice to Orally Administered Antigens},
  author={Meera Esvaran and Patricia Lynne Conway},
  booktitle={Vaccines},
  year={2016}
}
This study examined the influences of the dosage of the adjuvant, the nature of the antigen and the host genetics on the capacity of L. fermentum PC1 (PC1) to function as an oral adjuvant. BALB/c and DBA/1 mice were vaccinated with either ovalbumin (OVA) or Salmonella Typhimurium on days 0 and 14, Mice were also dosed with the PC1 (10⁸ CFU or 10(11) CFU per dose per mouse) with the antigens (days 0 and 14) and alone (days -1 and 13). The higher PC1 dose elicited a greater specific serum IgG2a… CONTINUE READING