Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.

@article{Fogelman1981FactorsRT,
  title={Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.},
  author={Alan M. Fogelman and Margaret E. Haberland and Joni Seager and M M Hokom and Peter A. Edwards},
  journal={Journal of lipid research},
  year={1981},
  volume={22 7},
  pages={1131-41}
}
Improved techniques of cell isolation resulted in 90 to 100 million monocytes from a single donor. Addition of low density lipoprotein (LDL) to to cultures of these cells resulted in the down regulation of LDL receptor activity. Addition of malondialdehyde-altered LDL. which enters the cell through a receptor for negatively charged proteins (the scavenger receptor), produced an even greater down regulation of the LDL receptor, indicating that both receptors are present on the same cell. Within… CONTINUE READING