Factors predicting severe infections during chemotherapy in head and neck cancer patients.


CONCLUSIONS The head and neck cancer patients with more co-morbidities and those dependent on tube feeding are at a high risk of severe infections during chemotherapy. Therefore, prophylaxis with colony-stimulating factors and/or antibiotics should be considered for those patients. OBJECTIVES To investigate the risk factors for severe infection during chemotherapy in head and neck cancer patients. METHODS A retrospective study was conducted of 129 patients with head and neck cancer who received taxane-based and platinum-based chemotherapy between 2008-2013. Logistic regression models were used to evaluate risk factors. RESULTS Febrile neutropenia occurred in 50 patients out of the 129 (39%), severe infections occurred in 24 patients (19%), and bacteremia in two patients (2%). In univariate analysis, low serum albumin levels and tube feeding were significantly associated with severe infections (p = 0.015 and < 0.001, respectively). In multivariate analysis, the odds ratios for a higher modified Charlson co-morbidity index and tube feeding were 2.80 and 9.74, respectively. These two were independent predictive factors for severe infections (p = 0.020 and 0.001, respectively).

DOI: 10.3109/00016489.2015.1060631

Cite this paper

@article{Sasaki2015FactorsPS, title={Factors predicting severe infections during chemotherapy in head and neck cancer patients.}, author={Takahiro Sasaki and Yukinori Takenaka and Tarou Hayashi and Masashi Yamamoto and Hironori Cho and Takahito Fukusumi and Norihiko Takemoto and Atsushi Hanamoto and Toshimichi Yasui and Susumu Nakahara and Yoshifumi Yamamoto and Kenji Mitani and Hidenori Inohara}, journal={Acta oto-laryngologica}, year={2015}, volume={135 10}, pages={1086-91} }