Factors modifying the head-twitch response to 5-hydroxytryptophan

  title={Factors modifying the head-twitch response to 5-hydroxytryptophan},
  author={C. Suzanne Boulton and Sheila L. Handley},
Factors modifying the head twitch response to 5-hydroxy d,l-tryptophan (5-HTP) have been investigated in the mouse. Stage of oestrous cycle and time of day had no effect. Local anaesthesia of the pinna region virtually abolished the response. Painting the pinnae with xylene increased the response and also increased the spontaneous head twitch rate. A concurrent variable frequency sound reduced the head twitch rate as did isolation. These results suggest that sensory input from the pinna is a… CONTINUE READING

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