Factors influencing the establishment of the intestinal microbiota in infancy.
@article{Adlerberth2008FactorsIT,
title={Factors influencing the establishment of the intestinal microbiota in infancy.},
author={Ingegerd Adlerberth},
journal={Nestle Nutrition workshop series. Paediatric programme},
year={2008},
volume={62},
pages={
13-29; discussion 29-33
}
}The establishment of the intestinal microbiota commences at birth and new bacteria establish in succession during the first years of life until an adult-type highly complex microbiota has been achieved. The first bacteria to establish in the neonatal gut are usually aerobic or facultatively anaerobic bacteria, like enterobacteria, enterococci and staphylococci. During their growth they consume oxygen and change the intestinal milieu making it suitable for the proliferation of anaerobic bacteria…
91 Citations
Early colonization of functional groups of microbes in the infant gut.
- BiologyEnvironmental microbiology
- 2016
The early establishment of GM with a novel perspective is presented and the importance of lactate utilization in infancy is emphasized, as mode of delivery is identified as a strong determinant for lactate-producing and -utilizing bacteria levels.
Neonatal microbiota development and the effect of early life antibiotics are determined by two distinct settler types
- MedicinePloS one
- 2020
It is hypothesize that stratification of children’s cohorts based on settler types may reveal group effects that might otherwise be masked in the first three months of life in term infants.
New Insights in Gut Microbiota Establishment in Healthy Breast Fed Neonates
- Biology, MedicinePloS one
- 2012
The presence of Bacteroidetes as pioneer bacteria in the majority of neonates studied demonstrates that adult-type strict anaerobes may reach adult-like population densities within the first week of life, which may occur earlier than previously assumed in breast-fed neonates.
High Abundance of Escherichia During the Establishment of Fecal Microbiota in Brazilian Children
- BiologyMicrobial Ecology
- 2014
The present results corroborate the global observation of inter-individual variability with an early establishment of microbial complexity at the end of the first year of life and highlight the presence of the Escherichia as abundant in microbiota composition of this group of children.
Establishment of Intestinal Microbiota during Early Life: a Longitudinal, Explorative Study of a Large Cohort of Danish Infants
- BiologyApplied and Environmental Microbiology
- 2014
It was found that significant changes in the gut microbiota occurred, particularly from age 9 to 18 months, when cessation of breastfeeding and introduction of a complementary feeding induce replacement of a microbiota characterized by lactobacilli, bifidobacteria, and Enterobacteriaceae with a microbiota dominated by Clostridium spp.
Bacterial colonization of the infantile bowel and the ileal pouch with focus on Escherichia coli
- Biology, Medicine
- 2010
These studies suggest that the bigger arsenal of virulence factor genes for extra-intestinal infections the longer E. coli can reside in the gut/pouch microbiota, however, different human populations differ in their E. bacteria composition and their traits favouring persistence in the Gut microbiota.
Intestinal microbiota composition after antibiotic treatment in early life: the INCA study
- Medicine, BiologyBMC Pediatrics
- 2015
There is evidence that manipulation of the infant microbiota by using pre- or probiotics can restore the ecological balance of the microbiota and may mitigate potential negative effects on the developing immune system, when use of antibiotics cannot be avoided.
Biodiversity of Beneficial Bacteria in Infant Feces and Their Potential Probiotic Functions
- Biology
- 2018
Among 6 healthy newborn infants, infant age and feeding type were the most influential factor for the population of bifidobacteria, clostridia, bacteroides, eubacteria and total bacteria, whereas feeding type and delivery mode were the main factors influencing total bacteria population.
The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection.
- Biology, MedicineMicrobiology spectrum
- 2015
It has become clear that the gut microbiota not only plays a major role in priming and regulating mucosal and systemic immunity, but that the immune system also contributes to host control over microbiota composition.
The long-term health effects of neonatal microbial flora
- Medicine, BiologyCurrent opinion in allergy and clinical immunology
- 2009
There is a complex interaction between the bacteria within the developing gut and the immune system of the host and it appears clear that disruption within this flora has long-term health consequences as diverse as eczema, allergic rhinitis, and IBD.
References
SHOWING 1-10 OF 105 REFERENCES
Fecal Microbial Community in Preterm Infants
- MedicineJournal of pediatric gastroenterology and nutrition
- 2005
The composition of fecal microbial community in preterm infants from the colonization of sterile gut is described, the different factors that contribute to its alterations are presented, and the gut microflora to diseases such as NEC is linked.
Factors Influencing the Composition of the Intestinal Microbiota in Early Infancy
- MedicinePediatrics
- 2006
The most important determinants of the gut microbiotic composition in infants were the mode of delivery, type of infant feeding, gestational age, infant hospitalization, and antibiotic use by the infant.
Development of bacterial and bifidobacterial communities in feces of newborn babies.
- Biology, MedicineAnaerobe
- 2003
Composition and ecology of the human intestinal flora
- BiologyAntonie van Leeuwenhoek
- 2004
Three of the Bacteroides fragilis strains tested were able to grow on “natural intestinal substrates” as gastric mucin, glycogen and a variety of plant polysaccharides and acetic, lactic, propionic and succinic acids were detected as fermentation products.
Reduced Enterobacterial and Increased Staphylococcal Colonization of the Infantile Bowel: An Effect of Hygienic Lifestyle?
- Medicine, BiologyPediatric Research
- 2006
It is shown that some “traditional” fecal bacteria are acquired late today especially in cesarean section–delivered infants, probably due to limited environmental circulation, and skin bacteria like staphylococci have become the first gut colonizers.
Intestinal bacteria of newborn Ethiopian infants in relation to antibiotic treatment and colonisation by potentially pathogenic gram-negative bacteria.
- MedicineScandinavian journal of infectious diseases
- 1991
There were no consistent changes of the microflora attributable to antibiotic treatment in newborn infants in Addis Ababa, and Colonisation by potentially pathogenic gram-negative bacteria was coupled to a low isolation rate of bifidobacterium, but not of lactobacillus.
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
- Biology, MedicineApplied and Environmental Microbiology
- 2002
This study showed that using PCR-DGGE and 16S rDNA sequence analysis together resulted in a dynamic description of bacterial colonization in the infant intestinal ecosystem and allowed visualization of bacteria that are difficult to cultivate or to detect by other methods.
Escherichia coli in Infants' Intestinal Microflora: Colonization Rate, Strain Turnover, and Virulence Gene Carriage
- Biology, MedicinePediatric Research
- 2003
The results confirm that P fimbriae and other virulence factors facilitate persistence of E. coli in the human colonic microflora.
INTESTINAL COLONIZATION OF BREAST‐FED CHILDREN IN A RURAL AREA OF LOW SOCIOECONOMIC LEVEL *
- Medicine
- 1971
This report deals with the intestinal colonization of breast-fed village children studied in their own environment by means of a design that retains at a minimum disturbance of the customs and living conditions of the inhabitants, and concerns the anaerobic and facultative flora, with some emphasis on the E. coli group.
Development and differences of intestinal flora in the neonatal period in breast-fed and bottle-fed infants.
- MedicinePediatrics
- 1983
The properties of breast milk that promote the growth of bifidobacteria and suppression of coliform and other potentially pathogenic organisms, theoretically, would help to minimize the incidence of neonatal diseases caused by these organisms.






