Factors influencing the effect size distribution of adaptive substitutions.

  title={Factors influencing the effect size distribution of adaptive substitutions.},
  author={Emily L Dittmar and Christopher G Oakley and Jeffrey K Conner and Billie A. Gould and Douglas W. Schemske},
  journal={Proceedings. Biological sciences},
  volume={283 1828}
The distribution of effect sizes of adaptive substitutions has been central to evolutionary biology since the modern synthesis. Early theory proposed that because large-effect mutations have negative pleiotropic consequences, only small-effect mutations contribute to adaptation. More recent theory suggested instead that large-effect mutations could be favoured when populations are far from their adaptive peak. Here we suggest that the distributions of effect sizes are expected to differ among… CONTINUE READING
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