Factors influencing outcomes in the offspring of mothers with phenylketonuria during pregnancy: the importance of variation in maternal blood phenylalanine.

@article{Maillot2008FactorsIO,
  title={Factors influencing outcomes in the offspring of mothers with phenylketonuria during pregnancy: the importance of variation in maternal blood phenylalanine.},
  author={François Maillot and Maggie F Lilburn and Jenny Baudin and David Morley and Philip S. Lee},
  journal={The American journal of clinical nutrition},
  year={2008},
  volume={88 3},
  pages={700-5}
}
BACKGROUND Developmental delay in the offspring of women with phenylketonuria (PKU) can be prevented by maintaining maternal blood phenylalanine (Phe) within a target range (100-250 micromol/L). OBJECTIVE We aimed to analyze outcomes in the offspring of women with PKU during pregnancy and to identify prognostic factors. DESIGN Occipitofrontal circumference at birth (OFC-B); developmental scores [developmental quotient (DQ) and intelligence quotient (IQ)]at 1, 4, 8, and 14 y; and the time of… CONTINUE READING

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