Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior.

@article{Levoe2014FactorsIA,
  title={Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior.},
  author={S Nikki Levoe and Brenna M. Flannery and Laurie L Brignolo and Denise M Imai and Amanda L. Koehne and Adam T Austin and Donald A Bruun and Daniel J. Tancredi and Pamela J Lein},
  journal={Current neurobiology},
  year={2014},
  volume={5 1-2},
  pages={1-10}
}
Repeated subcutaneous (s.c.) injection is a common route of administration in chronic studies of neuroactive compounds. However, in a pilot study we noted a significant incidence of skin abnormalities in adult male Long-Evans rats receiving daily s.c. injections of peanut oil (1.0 ml/kg) in the subscapular region for 21 d. Histopathological analyses of the… CONTINUE READING