Factors inducing periodic breathing in humans: a general model.

  title={Factors inducing periodic breathing in humans: a general model.},
  author={M C Khoo and Richard E. Kronauer and Kingman P Strohl and Arthur S Slutsky},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  volume={53 3},
A general model is developed to account for all kinds of periodic breathing (PB) resulting from instability in respiratory control: in normals during sleep and on acute exposure to high altitude, in sleeping infants, and in patients with cardiovascular or neurologic lesions. It is found that in almost every case the ventilatory oscillation is mediated predominantly by the peripheral controller. System stability is decreased by hypoxia, hypercapnia, increased lung washout times, prolonged lung… CONTINUE READING
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