Factors directly affecting impulse transmission in inflammatory demyelinating disease: recent advances in our understanding.

@article{Smith2001FactorsDA,
  title={Factors directly affecting impulse transmission in inflammatory demyelinating disease: recent advances in our understanding.},
  author={Kenneth J. Smith and Susan M. Hall},
  journal={Current opinion in neurology},
  year={2001},
  volume={14 3},
  pages={289-98}
}
Demyelination and inflammation both contribute to the neurological deficits characteristic of multiple sclerosis and Guillain-Barré syndrome. Conduction deficits attributable to demyelination are well known, but it is becoming clear that factors such as nitric oxide, endocaine, cytokines, and antiganglioside antibodies also play significant roles. Demyelination directly affects conduction and also causes changes in both the distribution and repertoire of expressed axolemmal ion channels, which… CONTINUE READING

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