Factors determining cell killing by chemotherapeutic agents in vivo. I. Cyclophosphamide.

@article{vanPutten1970FactorsDC,
  title={Factors determining cell killing by chemotherapeutic agents in vivo. I. Cyclophosphamide.},
  author={L. M. van Putten and P. Lelieveld},
  journal={European journal of cancer},
  year={1970},
  volume={6 4},
  pages={
          313-21
        }
}
Abstract The effect of various chemotherapeutic agents in vivo on the survival of mouse haemopoietic spleen colony-forming cells and osteosarcoma cells is compared and a detailed study is made of the dose-effect curve of cyclophosphamide for the haemopoietic stem cells in normal-mouse bone marrow and in rapidly repopulating spleen. Different parts of the dose-effect curve could be attributed to different mechanisms and it was evident that cyclophosphamide is more effective against rapidly… Expand
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