Factors contributing to the outcome of oxidative damage to nucleic acids

@article{Evans2004FactorsCT,
  title={Factors contributing to the outcome of oxidative damage to nucleic acids},
  author={M. Evans and M. Cooke},
  journal={BioEssays},
  year={2004},
  volume={26}
}
Oxidative damage to DNA appears to be a factor in cancer, yet explanations for why highly elevated levels of such lesions do not always result in cancer remain elusive. Much of the genome is non‐coding and lesions in these regions might be expected to have little biological effect, an inference supported by observations that there is preferential repair of coding sequences. RNA has an important coding function in protein synthesis, and yet the consequences of RNA oxidation are largely unknown… Expand
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TLDR
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TLDR
The present work reviews the basis for the biological significance of DNA damage, particu- larly effects of 8-oxoGua and ethenoadduct occurrence in DNA in the aspect of cancer development, drawing attention to the multiplicity of proteins with repair activities. Expand
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TLDR
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TLDR
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TLDR
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TLDR
There appears to be links between ingestion of antioxidant-containing foods or tablets of antioxidants, oxidative damage to DNA, and risk of cancer. Expand
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TLDR
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Stress Marks on the Genome: Use or Lose?
TLDR
Emerging data also indicate that oxidative base modifications such as 8-oxoG in gene promoters may serve as epigenetic marks, and/or provide a platform for coordination of the initial steps of DNA repair and the assembly of the transcriptional machinery to launch adequate gene expression alterations. Expand
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