Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation - description of a novel in vitro model.

@article{Ehnert2015FactorsCI,
  title={Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation - description of a novel in vitro model.},
  author={Sabrina Ehnert and Thomas Freude and Christoph Ihle and Larissa Mayer and Bianca Braun and Jessica Graeser and Ingo Flesch and U. St{\"o}ckle and Andreas K Nussler and Stefan Pscherer},
  journal={Experimental cell research},
  year={2015},
  volume={332 2},
  pages={247-58}
}
Type 2 diabetes mellitus (T2DM) is one of the most frequent metabolic disorders in industrialized countries. Among other complications, T2DM patients have an increased fracture risk and delayed fracture healing. We have demonstrated that supraphysiological glucose and insulin levels inhibit primary human osteoblasts׳ maturation. We aimed at developing a more physiologically relevant in vitro model to analyze T2DM-mediated osteoblast changes. Therefore, SCP-1-immortalized pre-osteoblasts were… CONTINUE READING
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