Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis.

@article{Hoekstra2003FactorsAW,
  title={Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis.},
  author={Monique Hoekstra and Annelies E van Ede and Cees J. Haagsma and Mart A.F.J. van de Laar and Thomas W. J. Huizinga and Marijn W. M. Kruijsen and Roland F J Laan},
  journal={Annals of the rheumatic diseases},
  year={2003},
  volume={62 5},
  pages={
          423-6
        }
}
  • Monique Hoekstra, Annelies E van Ede, +4 authors Roland F J Laan
  • Published in
    Annals of the rheumatic…
    2003
  • Medicine
  • OBJECTIVE To study factors associated with toxicity, final dose, and efficacy of methotrexate (MTX) in patients with rheumatoid arthritis (RA). METHODS Data were used from a randomised clinical 48 week trial on 411 patients with RA all treated with MTX, comparing folates and placebo. Logistic regression was used to study the relation between baseline variables and various dependent factors, including hepatotoxicity (alanine aminotransferase >/=3 x upper limit of normal), MTX withdrawal, final… CONTINUE READING

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