Factors altering thyroid hormone metabolism.

@article{Robbins1981FactorsAT,
  title={Factors altering thyroid hormone metabolism.},
  author={Jeffrey Robbins},
  journal={Environmental Health Perspectives},
  year={1981},
  volume={38},
  pages={65 - 70}
}
Thyroxine, the major secretory product of the thyroid gland, is metabolized in the peripheral tissues by phenolic conjugation, deamination, decarboxylation, and a cascade of monodeiodinations. This brief review focuses on the deiodination reactions, which currently are under intensive investigation. One product, 3,5,3'-triiodothyronine (T3), is the major active form of the thyroid hormone, and about 80% of the T3 produced in the body is derived extrathyroidally. Furthermore, a greater fraction… CONTINUE READING

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