Factors altering thyroid hormone metabolism.

  title={Factors altering thyroid hormone metabolism.},
  author={Jeffrey Robbins},
  journal={Environmental Health Perspectives},
  pages={65 - 70}
Thyroxine, the major secretory product of the thyroid gland, is metabolized in the peripheral tissues by phenolic conjugation, deamination, decarboxylation, and a cascade of monodeiodinations. This brief review focuses on the deiodination reactions, which currently are under intensive investigation. One product, 3,5,3'-triiodothyronine (T3), is the major active form of the thyroid hormone, and about 80% of the T3 produced in the body is derived extrathyroidally. Furthermore, a greater fraction… CONTINUE READING


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Role of intracellular glutathione in modulation of T 4 to T 3 conversion and hormone production by cultured pituitary cells

  • S. Melmed, M. Nelson, N. Kaplowitz, T. Yamada, J. M. Hershman
  • Proc . 8 th International Thyroid Congress
  • 1980

Thyroxine 5 'deiodination in rat anterior pituitary homogenates

  • M. M. Kaplan
  • Endocrinology
  • 1980

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