Factors affecting voluntary morphine intake in self-maintained addicted rats

@article{Weeks1964FactorsAV,
  title={Factors affecting voluntary morphine intake in self-maintained addicted rats},
  author={James R. Weeks and Robert J. Collins},
  journal={Psychopharmacologia},
  year={1964},
  volume={6},
  pages={267-279}
}
Self-maintained morphine addicted rats were prepared by implanting chronic venous cannulas and fitting the rats with a device permitting relatively free movement and also enabling them to obtain morphine injections at will by pressing a lever. Three factors modifying voluntary morphine intake were studied. 1. Using a continuous reinforcement schedule, progressively decreasing the size of the morphine dose led to a greater number of doses daily. Compensation was incomplete in that the total… CONTINUE READING
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