Factors affecting voluntary morphine intake in self-maintained addicted rats

  title={Factors affecting voluntary morphine intake in self-maintained addicted rats},
  author={James R. Weeks and Robert J. Collins},
Self-maintained morphine addicted rats were prepared by implanting chronic venous cannulas and fitting the rats with a device permitting relatively free movement and also enabling them to obtain morphine injections at will by pressing a lever. Three factors modifying voluntary morphine intake were studied. 1. Using a continuous reinforcement schedule, progressively decreasing the size of the morphine dose led to a greater number of doses daily. Compensation was incomplete in that the total… CONTINUE READING
30 Citations
14 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 30 extracted citations


Publications referenced by this paper.
Showing 1-10 of 14 references

Chronic intravenous caanulas for rats

  • J. D. DAvIs
  • J. appl. Physiol
  • 1964

SChUSTeR: Morphine self-administration, food reinforced and avoidance behaviors in rhesus monkeys

  • T. ToPsoN, R C.
  • Psychopharmacologia (Berl.)
  • 1964

W]~EKS: Fashioning polyethylene tubing for use in physiological experiments

  • N. G. HATTEY, R J.
  • J. appl. Physiol
  • 1964

EA])Es: Factors regulating oral consumption of an opioid (etonitazene) by morphine-addicted rats

  • W. R. MnTI, F. T. PESCOR, G C.
  • Psyehopharmacologia (Berl.)
  • 1963

Physiological aspects of tolerance and physical dependence, Section F in Physiological Pharmacology, Vol. 1 (W

  • M.H, G.A.DENEu
  • S. Root and F. G. HOt,ANN,
  • 1963

HVIDOB~O: The influence of some drugs on the abstinence syndrome to morphine in mice

  • Arch. int. Pharmacodyn. 188,
  • 1962

Self-maintained morphine "addiction"--a method for chronic programmed intravenous injections in unrestrained rats

  • J. R. WExs
  • Fed. Proc. 20,
  • 1961

Similar Papers

Loading similar papers…