Factors affecting the uptake of calcium by canine myocardial sarcoplasmic reticulum

@article{Baird1969FactorsAT,
  title={Factors affecting the uptake of calcium by canine myocardial sarcoplasmic reticulum},
  author={Taylor J. Baird and PeterF. Binnion},
  journal={Irish Journal of Medical Science (1968-1970)},
  year={1969},
  volume={2},
  pages={585-593}
}
Summary1.Cardiac sarcoplasmic reticulum was prepared from canine ventricular muscle by differential centrifugation of a muscle homogenate and was purified in a surose gradient and the mean protein yield was 48.2 mg. per 100 gram myocardium. The uptake of45calcium was measured under various experimental conditions.2.In the presence of 2×10−4 M calcium chloride the uptake of45Ca was 1 micromole per mg. protein after eight minutes although there was slight variation from experiment to experiment… 
3 Citations

Time- and rate-dependence of the inotropic action of noradrenaline in the isolated guinea-pig's atrium

The inotropic action of noradrenaline is minimal at a high rate in the fresh preparation and is fully developed only during later stages of perfusion at a low rate (which is far below the physiological range).

The influence of calcium and β-sympathomimetics on force-frequency relationship and resting potentiation in guinea pig papillary muscle

It is suggested that calcium and orciprenaline strenghten the calcium loss from the sarcoplasmic reticulum out of the cell during a prolonged interval.

Effects of Catecholamines on Metabolism

The concept that adenylcyclase may be very closely associated with the adrenergic receptor, first clearly formulated by Robison, Butcher and Sutherland (1967) has opened up the possibility that all effects of catecholamines may ultimately be described in biochemical terms.

References

SHOWING 1-10 OF 15 REFERENCES

The Effect of Quinidine on Calcium Accumulation by Isolated Sarcoplasmic Reticulum of Skeletal and Cardiac Muscle

The effect of quinidine on the skeletal sarcoplasmic reticulum supports the hypothesis that this compound produces twitch potentiation and contracture by interfering with intracellular calcium, sequestration.

Cardiac Sarcotubular Vesicles: EFFECTS OF IONS, OUABAIN AND ACETYLSTROPHANTHIDIN

  • M. Carsten
  • Biology, Chemistry
    Circulation research
  • 1967
It is suggested that the partial inhibition of calcium uptake increases the concentraton of free calcium, and thus makes more calcium available for contraction of the myofibril.

Calcium Uptake Activity of Canine Myocardial Sarcoplasmic Reticulum in the Presence of Anesthetic Agents

The anesthetics chloroform and halothane depressed calcium uptake and calcium-stimulated ATPase activity in parallel, indicating that these agents do not uncouple transport from ATP hydrolysis.

Activity of the Vesicular Calcium Pump in the Spontaneously Failing Heart‐Lung Preparation

Calcium uptake and adenosine triphosphatase activity were found to be proportionately depressed in the failing heart and proportionately restored by ouabain.

THE ACTION OF CARDIAC GLYCOSIDES ON ION MOVEMENTS.

  • I. Glynn
  • Biology, Medicine
    Pharmacological reviews
  • 1964
It is difficult to summarise when so much that has been said is tentative but it is probably fair to state that it is doubtful whether therapeutic doses of cardiac glycosides cause appreciable lowering of the internal potassium concentration.

DENSITY GRADIENT SEPARATION OF SARCOTUBULAR VESICLES AND OTHER PARTICULATE CONSTITUENTS OF RABBIT MUSCLE

Relaxing activity in terms of inhibition of myofibrillar ATPase predominates among the lighter subfractions, increase of ATPase among the heavier, with some variability.

Effects of propranolol and its optical isomers on the radiocalcium uptake and the adenosine triphosphatases of skeletal and cardiac sarcoplasmic reticulum fractions (SRF).

The effects of the beta adrenergic blocking drugs, propranolol, pronethalol, MJ-1999 and N-isopropyl- p -nitrophenylethanolamine (INPEA), on the Ca ++ uptake and the adenosine triphosphatases

The effect of noradrenaline on the calcium uptake of the sarcoplasmic reticulum.

Evidence is presented that noradrenaline increases the rate of uptake of calcium by the sarcoplasmic reticulum, and a hypothesis is suggested which explains the positive inotropic effect of the drug.

Toxic effects of lignocaine on the circulation.

  • P. Binnion
  • Medicine, Biology
    British medical journal
  • 1968
This investigation was done to determine whether a continuous infusion of lignocaine could be used in all patients after myocardial infarction to suppress the common ventricular ectopic beats, and possibly act as a prophylactic measure to prevent arrhythmias causing further myocardIAL deterioration.