Factors affecting the ratio of different organic osmolytes in renal medullary cells.

@article{Moriyama1990FactorsAT,
  title={Factors affecting the ratio of different organic osmolytes in renal medullary cells.},
  author={Toshiki Moriyama and Arlyn Garc{\'i}a-P{\'e}rez and Maurice B. Burg},
  journal={The American journal of physiology},
  year={1990},
  volume={259 5 Pt 2},
  pages={F847-58}
}
Renal medullary cells contain high concentrations of sorbitol, inositol, glycerophosphorylcholine (GPC), and betaine, which balance the variably high osmolality of extracellular NaCl. We found that PAP-HT25 (rabbit renal medullary) cells in tissue culture increase their content of all four when medium osmolality is increased by adding NaCl and urea. However, this requires that betaine be added to medium in addition to customary constituents. Some factors affecting the mix of organic osmolytes… CONTINUE READING
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