Factors affecting the milk-to-plasma drug concentration ratio in lactating women: physical interactions with protein and fat.

@article{Fleishaker1987FactorsAT,
  title={Factors affecting the milk-to-plasma drug concentration ratio in lactating women: physical interactions with protein and fat.},
  author={Joseph C. Fleishaker and Nirmala Desai and Patrick McNamara},
  journal={Journal of pharmaceutical sciences},
  year={1987},
  volume={76 3},
  pages={189-93}
}
The factors that affect M/P (milk-to-plasma) ratios of several compounds were assessed in vitro using samples collected from four healthy lactating women. Three drugs were studied: diazepam, phenytoin, and propranolol. Serum and skim milk protein binding were determined by equilibrium dialysis at 37 degrees C. Skim-to-whole milk concentration ratios (S/M) were determined after incubation of whole milk at 37 degrees C for 1 h. Free fractions in serum and skim milk, respectively, were 0.013 and 0… CONTINUE READING