Factors affecting the assay of urinary 3-hydroxy pyridinium crosslinks of collagen as markers of bone resorption.

@article{Colwell1993FactorsAT,
  title={Factors affecting the assay of urinary 3-hydroxy pyridinium crosslinks of collagen as markers of bone resorption.},
  author={Amy S. Colwell and R. Graham G. Russell and Richard Eastell},
  journal={European journal of clinical investigation},
  year={1993},
  volume={23 6},
  pages={341-9}
}
The measurement of the 3-OH pyridinium compounds, pyridinoline (Pyr) and deoxypyridinoline (Dpyr), in urine by high performance liquid chromatography is potentially useful in clinical studies, since they are specific biochemical markers of bone resorption. The aims of the present study were to improve assay performance and optimize sample collection. An isocratic high performance liquid chromatogram (HPLC) separation with baseline resolution was accomplished within 4 min using… CONTINUE READING
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