Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection.

@article{Laverman2001FactorsAT,
  title={Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection.},
  author={Peter Laverman and Myrra G. Carstens and Otto C Boerman and Els T. M. Dams and Wim J. G. Oyen and Nico Van Rooijen and Frans H. M. Corstens and Gerrit Storm},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={298 2},
  pages={607-12}
}
Previously, we showed that long-circulating polyethylene glycol (PEG)-liposomes are cleared rapidly from the circulation when injected repeatedly in the same animal. In this article, we describe the effects of PEG-coating, the circulation time, the lipid dose, and the presence of encapsulated doxorubicin on the pharmacokinetics upon repeated injection in rats. Furthermore, the role of liver and splenic macrophages was investigated. Liposomes without PEG-coating also showed the so-called… CONTINUE READING