Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy.

@article{Buckmaster2012FactorsAO,
  title={Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy.},
  author={Paul S Buckmaster and Megan Haney},
  journal={Epilepsy research},
  year={2012},
  volume={102 3},
  pages={153-9}
}
Pilocarpine-treated mice are an increasingly used model of temporal lobe epilepsy. However, outcomes of treatment can be disappointing, because many mice die or fail to develop status epilepticus. To improve animal welfare and outcomes of future experiments we analyzed results of previous pilocarpine treatments to identify factors that correlate with development of status epilepticus and survival. All treatments were performed by one investigator with mice of the FVB background strain. Results… CONTINUE READING

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