Factors affecting membrane permeability and ionic homeostasis in the cold-submerged frog.

@article{Donohoe2000FactorsAM,
  title={Factors affecting membrane permeability and ionic homeostasis in the cold-submerged frog.},
  author={Paul H Donohoe and Timothy G. West and Robert G. Boutilier Boutilier},
  journal={The Journal of experimental biology},
  year={2000},
  volume={203 Pt 2},
  pages={405-14}
}
Frogs (Rana temporaria) were submerged at 3 degrees C in either normoxic (P(O2)=155 mmHg, P(O2)=20 kPa) or hypoxic (P(O2)=60 mmHg; P(O2)=8 kPa) water for up to 16 weeks, and denied air access, to mimic the conditions of an ice-covered pond during the winter. The activity of the skeletal muscle Na(+)/K(+) pump over the first 2 months of hibernation, measured by ouabain-inhibitable (22)Na(+) efflux, was reduced by 30 % during normoxia and by up to 50 % during hypoxia. The reduction in Na(+)/K… CONTINUE READING