Factors affecting autocatalysis of botulinum A neurotoxin light chain.

@article{Ahmed2004FactorsAA,
  title={Factors affecting autocatalysis of botulinum A neurotoxin light chain.},
  author={S. Ashraf Ahmed and Matthew L Ludivico and L. A. Smith},
  journal={The protein journal},
  year={2004},
  volume={23 7},
  pages={445-51}
}
The light chain of botulinum neurotoxin serotype A undergoes autocatalytic fragmentation into two major peptides during purification and storage (Ahmed S. A. et al. 2001, J. Protein Chem. 20:221-231) by both intermolecular and intramolecular mechanisms (Ahmed S. A. et al. 2003, Biochemistry 42:12539 12549). In this study, we investigated the effects of… CONTINUE READING