Factors affecting adherence to antiretroviral therapy.

@article{Chesney2000FactorsAA,
  title={Factors affecting adherence to antiretroviral therapy.},
  author={Margaret Chesney},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2000},
  volume={30 Suppl 2},
  pages={
          S171-6
        }
}
  • M. Chesney
  • Published 1 June 2000
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
In both clinical trials and clinical practice, nonadherence to medications is widespread among patients with chronic diseases. The shift to combination therapies for treating human immunodeficiency virus (HIV)-infected individuals has increased adherence challenges for both patients and health-care providers. Estimates of average rates of nonadherence to antiretroviral therapy range from 50% to 70%. Adherence rates of <80% are associated with detectable viremia in a majority of patients. The… 
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Younger age, higher number of pills, higher frequency of doses, and longer time on therapy were predictors of nonadherent behavior, while simpler regimens with a lower number of drugs and doses may help patients' compliance to therapy.
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