Factors Influencing the Properties of Rifampicin Liposome and Applications for Dry Powder Inhaler

  title={Factors Influencing the Properties of Rifampicin Liposome and Applications for Dry Powder Inhaler},
  author={Narumon Changsan and Teerapol Srichana},
  journal={2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems},
  • N. Changsan, T. Srichana
  • Published 2007
  • Materials Science
  • 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems
RIF encapsulated liposome vesicles were prepared by chloroform film method followed by freeze drying technique to obtain a dry powder for aerosol delivery. The freeze drying conditions were designed according to the DSC results of the liposome suspension. Three sugars (mannitol, lactose and trehalose) were used as a cryoprotectant of liposome dry powder. NR 8383 cell line was used to determine immunological activation and toxicity of liposome products when LPS from E.coli was used as a positive… Expand
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