Factors Influencing the Differentiation of Dopaminergic Traits in Transplanted Neural Stem Cells

@article{Yang2003FactorsIT,
  title={Factors Influencing the Differentiation of Dopaminergic Traits in Transplanted Neural Stem Cells},
  author={Ming Yang and Angela E. Donaldson and Yubao Jiang and Lorraine Iacovitti},
  journal={Cellular and Molecular Neurobiology},
  year={2003},
  volume={23},
  pages={851-864}
}
1. Our previous studies demonstrated that when neural stem cells (NSCs) of the C17.2 clonal line are transplanted into the intact or 6-hydroxydopamine (6-OHDA) lesioned rat striatum, in most, but not all grafts, cells spontaneously express the dopamine (DA) biosynthetic enzymes, tyrosine hydroxylase (TH), and aromatic L-amino acid decarboxylase (Yang, M., Stull, N. D., Snyder, E. Y., Berk, M. A., and Iacovitti, L. (2002). Exp. Neurol.). 2. These results suggested that there were certain… CONTINUE READING