Factors Controlling the Uptake of Yeast Copper/Zinc Superoxide Dismutase into Mitochondria*

  title={Factors Controlling the Uptake of Yeast Copper/Zinc Superoxide Dismutase into Mitochondria*},
  author={L. S. Field and Y. Furukawa and T. O’Halloran and V. Culotta},
  journal={Journal of Biological Chemistry},
  pages={28052 - 28059}
  • L. S. Field, Y. Furukawa, +1 author V. Culotta
  • Published 2003
  • Biology, Medicine
  • Journal of Biological Chemistry
  • We have previously shown that a fraction of yeast copper/zinc-superoxide dismutase (SOD1) and its copper chaperone CCS localize to the intermembrane space of mitochondria. In the present study, we have focused on the mechanism by which SOD1 is partitioned between cytosolic and mitochondrial pools. Using in vitro mitochondrial import assays, we show that only a very immature form of the SOD1 polypeptide that is apo for both copper and zinc can efficiently enter the mitochondria. Moreover, a… CONTINUE READING
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