• Corpus ID: 8124269

Factors Affecting the Concentration of Breath Components Physiological and Biological Variables

  title={Factors Affecting the Concentration of Breath Components Physiological and Biological Variables},
  author={Antony Manolls},
Although the use of breath tests, such as those for hydrogen and ‘4CO2, are comparatively well known (1-4), the use of metabolites or volatile compounds in the breath as markers for disease is not so widely known. The purpose of this paper is to review the literature on the diagnostic aspects of breath analysis. Breath analysis is noninvasive and, with recent developments, potentially rapid in application. Progress in breath analysis is dependent on technical development; therefore, a section… 

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Analysis of organic compounds in human breath by gas chromatography-mass spectrometry.
Breath analysis as a technique in clinical chemistry.
The requirements for obtaining breath samples in equilibrium with the pulmonary blood circulation are delineated, and experimental data are presented for the significant breath-sample characteristics bearing on design of breath collection and storage systems (end-expiration temperature, breath volumes).
[Use of tests based on the analysis of expired air in nutritional studies].
The nutritional application of the breath-analysis tests is discussed, and the advantages of the non-radioactive, non-invasive procedures, especially for use in children and pregnant women in whom standard investigational methods represent a discomfort or a radioactive hazard, are emphasized.
Animal breath data for estimating the exposure of humans to chlorinated hydrocarbons.
Nine rate-of-decay curves for four concentrations and five exposure times have been constructed and show that a change in concentration results in an equivalent shift in the quantity of the compound in the breath.
Biochemical profile or uremic breath.
It is concluded that uremic breath reflects the systemic accumulation of potentially toxic volatile metabolites, among which dimethylamine and trimethylamines have been positively identified and correlated with the classic fishy odor.
Use of breath analysis to monitor trichloroethylene exposures.
The series of T CE breath decay curves obtained was highly reproducible and the narrow range of TCE in the breath at a specific time in the early postexposure period of persons identically exposed indicated that breath analysis could be used as a rapid method with which to estimate the magnitude of recent TCE exposure.
Acetone in the Breath: A Study of Acetone Exhalation in Diabetic and Nondiabetic Human Subjects
A study of the free acetone content of the exhaled air from nonfasting diabetic and normal subjects, using two widely dissimilar yet highly sensitive methods for the determination of free acetOne in aliquots of the same sample of condensed exhaled vapor and the chemical micromethod of Greenberg and Lester.
Real-time analysis of breath using an atmospheric pressure ionization mass spectrometer.
A new technique resulting in the direct, instantaneous analyses of trace compounds in breath appears to be of potential value in routine detection and treatment of hyperammonemia patients and a number of diagnostic research applications.
Improved gas chromatographic quantitation of breath hydrogen by normalization to respiratory carbon dioxide.
It is shown that normalization of breath hydrogen values to an alveolar concentration, using the observed carbon dioxide concentrations, substantially reduces the range and variance of apparent H2 concentrations in human subjects and substantially increases the reliability and clinical utility of hydrogen breath measurements in noninvasive tests of carbohydrate mal absorption.
Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography.
By this technique, the composition of body fluids can be made constant after a few days, permitting significant quantitative analyses to be performed, and should be useful in the application of the principles of orthomolecular medicine.