This study examined the psychometric properties (specifically, the factorial invariance) of the Multidimensional Health Locus of Control scales in a multicultural sample of college students. The original 18-item MHLC was administered, along with measures of ethnicity-related variables, to 1845 college students from three ethnic groups (Caucasian Americans, Filipino Americans and Latino Americans). Confirmatory factor analysis failed to confirm a three-factor structure for any of the three groups. Subsequent exploratory principal components analysis supported a cross-ethnic-group three-factor structure that had reduced numbers of items loading adequately on each factor. Shortened scales were created, and internal consistency reliability for each scale was acceptable for each ethnic group. Filipino Americans scored higher on all three scales. Regression analyses predicting MHLC scales from demographic and sociocultural variables revealed few predictive relationships.