Factorial design optimization of micelle enhanced synchronous spectrofluorimetric assay of Omarigliptin: Applied to content uniformity testing and in vitro drug release.

@article{Ayoub2018FactorialDO,
  title={Factorial design optimization of micelle enhanced synchronous spectrofluorimetric assay of Omarigliptin: Applied to content uniformity testing and in vitro drug release.},
  author={Bassam M Ayoub and Shereen Mowaka and Mona Arafa},
  journal={Luminescence : the journal of biological and chemical luminescence},
  year={2018},
  volume={33 4},
  pages={797-805}
}
A micelle enhanced spectrofluorimetric method was developed for determination of Omarigliptin (OMG) based on its native fluorescence behavior. The interaction of OMG with surfactants and macromolecules was studied. In aqueous solution, the relative fluorescence intensity (RFI) of OMG was enhanced by 24% in the presence of Tween 80 at pH 3.5. The optimal… CONTINUE READING