Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet.

@article{Hayashi2011FactorFA,
  title={Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet.},
  author={Takahiro Hayashi and Yuriko Nozaki and Makoto Nishizuka and Masahito Ikawa and S. Osada and Masayoshi Imagawa},
  journal={Biological & pharmaceutical bulletin},
  year={2011},
  volume={34 8},
  pages={1257-63}
}
To clarify the molecular mechanism of adipocyte differentiation, we previously isolated a novel gene, factor for adipocyte differentiation (fad) 158, whose expression was induced during the earliest stages of adipogenesis, and its product was localized to the endoplasmic reticulum. We found that the knockdown of fad158 expression prevented the differentiation of 3T3-L1 cells into adipocytes. In addition, over-expression of fad158 promoted the differentiation of NIH-3T3 cells, which do not… CONTINUE READING

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