Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation.

@article{Borensztajn2008FactorXS,
  title={Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation.},
  author={Keren Borensztajn and Jurri{\"e}n Stiekema and Sebastiaan W R Nijmeijer and Pieter H. Reitsma and Maikel P Peppelenbosch and C. Arnold Spek},
  journal={The American journal of pathology},
  year={2008},
  volume={172 2},
  pages={309-20}
}
Coagulation proteases have been suggested to play a role in the pathogenesis of tissue remodeling and fibrosis. We therefore assessed the proinflammatory and fibroproliferative effects of coagulation protease factor (F)Xa. We show that FXa elicits a signaling response in C2C12 and NIH3T3 fibroblasts. FXa-induced ERK1/2 phosphorylation was dependent on protease-activated receptor (PAR)-2 cleavage because desensitization with a PAR-2 agonist (trypsin) but not a PAR-1 agonist (thrombin) abolished… CONTINUE READING

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