Factor XIIIa-catalyzed cross-linking of platelet and muscle actin. Regulation by nucleotides.

@article{Cohen1980FactorXC,
  title={Factor XIIIa-catalyzed cross-linking of platelet and muscle actin. Regulation by nucleotides.},
  author={Isaac Cohen and Tikoes A. Blankenberg and D Borden and Dr. Robert Kahn and Arthur Veis},
  journal={Biochimica et biophysica acta},
  year={1980},
  volume={628 3},
  pages={365-75}
}
Actin from human blood platelets or rabbit skeletal muscle can serve as substrate for factor XIIIa. The latter catalyzes the incorporation of 1.5-2 mol monodansylcadaverine/mol rabbit actin and 0.5 mol/mol platelet actin. Highly cross-linked platelet and muscle actin polymers form in the absence of added amines, indicating the presence of both acceptor and donor sites. As expected, the cross-link was found to be a gamma-glutamyl-epsilon-lysine bone, with an average of 0.3-0.4 mol dipeptide/mol… CONTINUE READING

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