Factor XIII activity levels in patients with allogeneic haematopoietic stem cell transplantation and acute graft-versus-host disease of the gut.

@article{Pihusch2002FactorXA,
  title={Factor XIII activity levels in patients with allogeneic haematopoietic stem cell transplantation and acute graft-versus-host disease of the gut.},
  author={Rudolf Pihusch and Christoph Salat and Peter Goehring and Markus Hentrich and Holger Wegner and Markus Pihusch and Erhard Hiller and H. Kolb and Helmut Ostermann},
  journal={British journal of haematology},
  year={2002},
  volume={117 2},
  pages={469-76}
}
Severe graft-versus-host disease (GvHD) of the gut clinically resembles Crohn's disease and ulcerative colitis. As low plasma levels of factor XIII (FXIII) have been described in chronic inflammatory bowel disease (CIBD) and as beneficial effects of FXIII concentrates in CIBD have been reported, we studied the FXIII plasma activity levels in patients undergoing allogeneic stem cell transplantation (SCT). In 20 of 22 patients with an uncomplicated course of SCT, FXIII stayed within the normal… CONTINUE READING