Factor XIII--an under diagnosed deficiency--are we using the right assays?

@article{Lawrie2010FactorXU,
  title={Factor XIII--an under diagnosed deficiency--are we using the right assays?},
  author={A. S. Lawrie and Louise Green and Ian Mackie and Ri Liesner and Samuel J. Machin and Flora Peyvandi},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2010},
  volume={8 11},
  pages={
          2478-82
        }
}
BACKGROUND   The clot solubility test is the most widely used method for detection of factor (F)XIII deficiency. However, it will only detect severe deficiencies; consequently mild deficiencies and heterozygous states are probably under diagnosed. OBJECTIVE As an alternative first-line screening test, we assessed an automated quantitative ammonia release assay (QARA). PATIENTS/METHODS Inter-assay imprecision was evaluated with commercial normal and pathological control plasmas (10… CONTINUE READING

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