Factor XII inhibition reduces thrombus formation in a primate thrombosis model.

  title={Factor XII inhibition reduces thrombus formation in a primate thrombosis model.},
  author={Anton G Matafonov and Philberta Y. Leung and Adam E Gailani and Stephanie L Grach and Cristina Puy and Qiufang Cheng and Mao-fu Sun and Owen J. T. McCarty and Erik I. Tucker and Hiroaki Kataoka and Thomas Renn{\'e} and James H Morrissey and Andr{\'a}s Gruber and David Gailani},
  volume={123 11},
The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety of mouse models. These proteins serve a limited role in hemostasis, suggesting that antithrombotic therapies targeting them may be associated with low bleeding risks. Although there is substantial epidemiologic evidence supporting a role for fXI in human thrombosis, the situation is not as clear for fXII. We generated monoclonal antibodies (9A2 and 15H8) against the human fXII heavy chain that… CONTINUE READING


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