Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation.

@article{Gailani1993FactorXA,
  title={Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation.},
  author={David Gailani and George J. Broze},
  journal={Blood},
  year={1993},
  volume={82 3},
  pages={813-9}
}
Factor XI (FXI) may be activated in a purified system by thrombin and by autoactivation in the presence of negatively charged substances such as dextran sulfate or sulfatides. The current studies were performed to determine if these processes occur during the coagulation of plasma. FXII--deficient plasma was supplemented with 125I-FXI and clot formation was induced with tissue factor and/or sulfatides. Cleavage of FXI was studied by standard polyacrylamide gel electrophoresis and… CONTINUE READING
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