Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques.

@article{Montfoort2014FactorXR,
  title={Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques.},
  author={Maurits L. van Montfoort and Marijke J E Kuijpers and V{\'e}ronique L. Knaup and Sanjay Bhanot and Brett P. Monia and Joris J.T.H. Roelofs and Johan W. M. Heemskerk and Joost C M Meijers},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2014},
  volume={34 8},
  pages={
          1668-73
        }
}
OBJECTIVE Coagulation factor XI is proposed as therapeutic target for anticoagulation. However, it is still unclear whether the antithrombotic properties of factor XI inhibitors influence atherosclerotic disease and atherothrombosis. Our aim is to investigate whether factor XI antisense oligonucleotides could prevent thrombus formation on acutely ruptured atherosclerotic plaques. APPROACH AND RESULTS Atherosclerotic plaques in the carotid arteries of Apoe(-/-) mice were acutely ruptured using… CONTINUE READING
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

Similar Papers

Loading similar papers…