Factor XI deficiency in animal models.

  title={Factor XI deficiency in animal models.},
  author={Thomas Renn{\'e} and Chris Oschatz and Stefanie Seifert and Felicitas M{\"u}ller and Joven Antovic and Mattias Karlman and Peter M Benz},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={7 Suppl 1},
The blood coagulation system forms fibrin to limit blood loss from sites of injury, but also contributes to occlusive diseases such as deep vein thrombosis, myocardial infarction, and stroke. In the current model of a coagulation balance, normal hemostasis and thrombosis represent two sides of the same coin; however, data from coagulation factor XI-deficient animal models have challenged this dogma. Gene targeting of factor XI, a serine protease of the intrinsic pathway of coagulation, severely… CONTINUE READING


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