Factor XI activation in a revised model of blood coagulation.

@article{Gailani1991FactorXA,
  title={Factor XI activation in a revised model of blood coagulation.},
  author={David Gailani and George J. Broze},
  journal={Science},
  year={1991},
  volume={253 5022},
  pages={909-12}
}
Coagulation factor XI is activated in vitro by factor XIIa in the presence of high molecular weight kininogen (HMWK) and a negatively charged surface. Factor XII deficiency is not associated with bleeding, which suggests that another mechanism for factor XI activation exists in vivo. A revised model of coagulation is proposed in which factor XI is activated by thrombin. In the absence of cofactors, thrombin is more effective (kcat/Km = 1.6 x 10(5)) than factor XIIa (1.7 x 10(4)) in activating… CONTINUE READING

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