Factor XI activation in a revised model of blood coagulation.

  title={Factor XI activation in a revised model of blood coagulation.},
  author={David Gailani and George J. Broze},
  volume={253 5022},
Coagulation factor XI is activated in vitro by factor XIIa in the presence of high molecular weight kininogen (HMWK) and a negatively charged surface. Factor XII deficiency is not associated with bleeding, which suggests that another mechanism for factor XI activation exists in vivo. A revised model of coagulation is proposed in which factor XI is activated by thrombin. In the absence of cofactors, thrombin is more effective (kcat/Km = 1.6 x 10(5)) than factor XIIa (1.7 x 10(4)) in activating… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 203 extracted citations

Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…